Compartmental nutritional status and respiratory muscle function assessment in subjects with neuromuscular diseases / Evaluación del estado nutricional compartimental y de la función muscular respiratoria en sujetos con enfermedades neuromusculares

Abstract There are few data devoted to the combined assessment of the nutritional and respiratory status of subjects with neuromuscular diseases. The objective was to establish correlations between com partmental nutritional variables and respiratory variables to identify respiratory muscle weakness determinants of patients with amyotrophic lateral sclerosis (ALS) and Duchenne muscular dystrophy (DMD). Cross-sectional study with ALS and DMD patients included in an Institutional Registry of Neuromuscular diseases. Nutritional status was assessed through body mass index (BMI), expected weight for zero muscle mass (ZMM%) and creatinine-height index (CHI%). Respiratory indices evaluated were spirometry, maximal static inspiratory and expiratory pressures at the mouth (MIP and MEP), and peak cough flow (PCF). A total of 36 ALS and 34 DMD patients were included. Both groups showed a decrease in the body muscle mass and an excess in body fat (p < 0.001). Only in the ALS group was there a weak uphill relationship between body mass index (BMI) and the respiratory variables. In both groups, the ZMM% index did not correlate with any respiratory variable. The CHI% showed the strongest (r > 0.700) positive linear relationship with FVC%, MIP%, MEP%, and PCF% in both ALS and DMD patients (p < 0.001).In this study our patients, BMI did not accurately reflect body composition and underestimated excess fat. This study puts into perspective the relevance of compartmental evaluation to assess respiratory muscle function and establishes that body muscle mass is the most relevant nutritional parameter in relation to respiratory muscle strength.

Resumen Hay pocos datos relativos a la evaluación combinada del estado nutricional y respiratorio de sujetos con enfermedades neuromusculares. El objetivo fue establecer correlaciones entre las variables nutricionales compartimentales y las variables respiratorias para identificar los determinantes de la debilidad de los músculos respiratorios de los pacientes con esclerosis lateral amiotrófica (ELA) y distrofia muscular de Duchenne (DMD). Estudio transversal con pacientes con ELA y DMD incluidos en el Registro Institucional de Enfermedades Neuromusculares. El estado nutricional se evaluó mediante el índice de masa corporal (IMC), el peso esperado para masa muscular cero (ZMM%) y el índice de creatinina-talla (CHI%). Los índices respiratorios evaluados fueron espirometría, presiones inspiratorias y espiratorias estáticas máximas en la boca (MIP y MEP) y flujo espiratorio pico tosido (PCF). Se incluyeron un total de 36 pacientes con ELA y 34 con DMD. Ambos grupos mostraron una disminución de la masa muscular corporal y un exceso de grasa corporal (p <0.001). Solo en el grupo ELA hubo una débil correlación positiva entre el IMC y las variables respiratorias. En ambos grupos, el índice ZMM% no se correlacionó con ninguna variable respiratoria. El CHI% mostró la relación lineal positiva más fuerte (r > 0.700) con FVC%, MIP%, MEP% y PCF% tanto en pacientes con ELA como con DMD (p < 0.001). El IMC no reflejó con precisión la composición corporal y subestimó el exceso de grasa. Este estudio pone en perspectiva la relevancia de la evaluación compartimental para evaluar la función de la musculatura respiratoria y establece que la masa muscular corporal es el parámetro nutricional más relevante en relación a la fuerza de la musculatura respiratoria.

Overview of standardized training programme for clinical application and quality control of pulmonary function testing in China / 中国实用内科杂志

Pulmonary function testing(PFT) is an appropriate technique for comprehensive prevention and control of chronic airway diseases. In 2015, the National Clinical Research Center for Respiratory Diseases launched the national standardized training and assessment programme on clinical application and quality control of PFT. There are four steps for the overall programme. The first step is to establish the standard and outline of standardized training for PFT. The second step is to carry out standardized training based on the established standard and outline. The third step is to conduct post-training assessment, evaluate the training effect, and certify the trainees who master the training content. The last step is to carry out quality control in those who have obtained the certification,and evaluate the application of training content in clinical practice. With the progress of the programme, clinicians' awareness of the importance of PFT will be increased, physicians' and techinicians' operate on skills and clinical application abilities of PFT will be promoted, while the qualities of PFT in China will be improved. It will be of great significance to the construction of Pulmonary and Critical Care Medicine(PCCM).

The development and future of pulmonary function testing in children in China / 国际儿科学杂志

The research and clinical application of pulmonary function testing in children in China has a history of more than 50 years, which started in the 1960s and developed rapidly during the past two decades.Chinese scholars have explored the normal reference values, standard of bronchodilation test and applications in the diagnosis and treatment of diseases of different pulmonary function tests in children, especially infants, and developed a series of guidelines to standardize the operations, reports and applications.In the past decade, the applications have been fully promoted, and quality control have been continuously improved through standardized training.At present, pulmonary function tests have become an important method in the diagnosis and treatment of respiratory diseases in children.

The development and future of pulmonary function testing in children in China / 国际儿科学杂志

The research and clinical application of pulmonary function testing in children in China has a history of more than 50 years, which started in the 1960s and developed rapidly during the past two dec-ades. Chinese scholars have explored the normal reference values, standard of bronchodilation test and applica-tions in the diagnosis and treatment of diseases of different pulmonary function tests in children, especially in-fants, and developed a series of guidelines to standardize the operations, reports and applications. In the past decade, the applications have been fully promoted, and quality control have been continuously improved through standardized training. At present, pulmonary function tests have become an important method in the di-agnosis and treatment of respiratory diseases in children.

Accuracy of maximal expiratory flow-volume curve curvilinearity and fractional exhaled nitric oxide for detection of children with atopic asthma / 소아과

PURPOSE: Airway pathology in children with atopic asthma can be reflected by the concave shape of the maximal expiratory flow-volume (MEFV) curve and high fractional exhaled nitric oxide (FeNO) values. We evaluated the capacity of the curvilinearity of the MEFV curve, FeNO, and their combination to distinguish subjects with atopic asthma from healthy individuals. METHODS: FeNO and angle β, which characterizes the general configuration of the MEFV curve, were determined in 119 steroid-naïve individuals with atopic asthma aged 8 to 16 years, and in 92 age-matched healthy controls. Receiver operating characteristic (ROC) curve analyses were performed to determine the cutoff points of FeNO and angle β that provided the best combination of sensitivity and specificity for asthma detection. RESULTS: Asthmatic patients had a significantly smaller angle β and higher FeNO compared with healthy controls (both, P<0.001). For asthma detection, the best cutoff values of angle β and FeNO were observed at 189.3° and 22 parts per billion, respectively. The area under the ROC curve for the combination of angle β and FeNO improved to 0.91 (95% confidence interval [CI], 0.87–0.95) from 0.80 (95% CI, 0.75–0.86; P<0.001) for angle β alone and 0.86 (95% CI, 0.82–0.91; P=0.002) for FeNO alone. In addition, the combination enhanced sensitivity with no significant decrease in specificity. CONCLUSION: These data suggest that the combined use of the curvilinearity of the MEFV curve and FeNO is a useful tool to differentiate between children with and without atopic asthma.

Practice in standardized training for medical operators in childhood pulmonary function testing / 中华医学教育探索杂志

Pulmonary function testing (PFT) is a widely used method in early screening, severity evaluating and outcome predicting of lung diseases. In the practice of standardized training of pulmonary function tests, through the problem-based theory teaching and participative teaching and so on, we made the lung function inspection personnel to realize the examination operation essentials, and through situational teaching, we also cultivated the inspection personnel to master the communication skills with the children, so as to improve their professional quality, and ensure the effectiveness of the quality control of pulmonary function.

Functional exercise capacity, lung function and chest wall deformity in patients with adolescent idiopathic scoliosis / Capacidade funcional de exercício, função pulmonar e geometria da caixa torácica em pacientes com escoliose idiopática do adolescente

AbstractIntroduction The adolescent idiopathic scoliosis (AIS) causes changes on the compliance of the chest. These changes may be associated with impaired lung function and reduced functional exercise capacity of these adolescents. We aimed to evaluate the correlation between functional exercise capacity, lung function and geometry of the chest at different stages of AIS.Materials and methods The study was carried out in a cross-sectional design which were evaluated 27 AIS patients at different stages of the disease. For chest wall evaluation, were created geometry angles/distances (A/D), which were quantified by Software Postural Assessment. The functional exercise capacity was assessed by a portable gas analyzer during the incremental shuttle walk test (ISWT). Besides that, manovacuometry and spirometry were also performed.Results Linear regressions showed that oxygen uptake (peak VO2) was correlated with distance travelled in the ISWT (R2 = 0.52), maximal respiratory pressures, cough peak flow (R2 = 0.59) and some thoracic deformity markers (D1, D2 and A6).Discussion We observed that the chest wall alterations, lung function and respiratory muscle strength are related to the functional exercise capacity and may impair the physical activity performance in AIS patients.Final considerations There is correlation between functional exercise capacity, lung function and geometry of the chest in AIS patients. Our results point to the possible impact of the AIS in the physical activities of these adolescents. Therefore, efforts to prevent the disease progression are extremely important.

ResumoIntrodução A escoliose idiopática do adolescente (EIA) provoca alterações na conformidade da caixa torácica. Essas alterações podem estar associadas ao prejuízo da função pulmonar e à redução da capacidade funcional de exercício desses adolescentes.Materiais e métodos O estudo foi realizado em delineamento transversal no qual foram avaliadas a correlação entre a capacidade funcional de exercício, função pulmonar e a geometria da caixa torácica de 27 pacientes em diferentes estágios da EIA. Para avaliação da geometria torácica foram criados ângulos/distâncias (A/D) que foram quantificados pelo Software de Avaliação Postural. Foram realizadas manovacuometria, espirometria e a capacidade funcional de exercício foi avaliada por meio de um analisador de gases portátil durante o incremental shuttle walk test (ISWT).Resultados As regressões lineares mostraram que o consumo de oxigênio se correlacionou com a distância caminhada no ISWT (R2 = 0,52), as pressões respiratórias máximas, o pico de fluxo de tosse (R2 = 0,59) e alguns marcadores de deformidade torácica (D1, D2 e A6).Discussão Observamos que a alteração da geometria da caixa torácica, a função pulmonar e a força dos músculos respiratórios estão associadas à capacidade funcional de exercício e podem prejudicar o desempenho das atividades físicas dos pacientes com EIA.Considerações finais Existe correlação entre a capacidade funcional de exercício, função pulmonar e a geometria da caixa torácica em pacientes com EIA. Nossos resultados apontam o possível impacto da EIA nas atividades físicas desses adolescentes.

A utilização dos testes de função pulmonar na avaliação pré-operatória / Pulmonary function testing in the preoperative evaluation

A avaliação pulmonar pré-operatória é realizada para estimar o risco de ocorrência de complicações pulmonares no pós-operatório. Esse risco varia na dependência do sítio operatório, da anestesia utilizada e do estado clínico dos doentes, sendo que a presença de pneumopatia crônica pode elevá-lo. Os testes de função pulmonar durante a avaliação pré-operatória têm múltiplas finalidades: diagnosticar e graduar a intensidade dos distúrbios, indicar o melhor tratamento, otimizando-o, fornecer valores de corte que podem diferenciar risco aceitável de risco alto para complicações e eventualmente induzir a mudança de estratégia operatória ou descartar essa modalidade de tratamento. Inicialmente espirometria e gasometria arterial eram os únicos exames disponíveis para tal, mas, atualmente, podemos contar com outros exames como a medida da capacidade de difusão pulmonar para o monóxido de carbono, pressões respiratórias máximas, teste de exercício cardiopulmonar e testes de exercício de campo. O objetivo desta revisão é apresentar os testes de função pulmonar utilizados rotineiramente na avaliação pré-operatória e como eles são capazes de contribuir com essa avaliação.

Preoperative pulmonary evaluation is performed to estimate risk of postoperative pulmonary complications. Risk depends on the operative site, type of anesthesia and clinical status of patient. Chronic lung disease may increase this risk. Pulmonary function testing during the preoperative evaluation has multiple purposes: establish the diagnosis and severity of disorders, indicate the most appropriate treatment, provide cutoff values that can establish high risk for complications. In this case it is possible to change operative strategy or offer another treatment option. Initially spirometry and blood gases analysis were the only tests available for that, but now we can rely on other tests such as measurement of diffusing capacity for carbon monoxide, respiratory muscle strength, cardiopulmonary exercise testing and field testing. The aim of this review is to present the pulmonary function tests usually used in preoperative evaluation and how they are able to contribute in this field.

Investigation of the optimal surrogate for forced vital capacity in the diagnosis for chronic obstructive pulmonary disease / 中国综合临床

Objective To evaluate whether the forced expiratory volume in sixth scend(FEV6) was the optimal surrogate for forced vital capacity (FVC) in the diagnosis for chronic obstructive pulmonary disease (COPD).Methods Retrospectively analyzed the spirometric data of 142 COPD patients (7 cases with mild COPD,60 cases with moderate COPD,48 cases with severe COPD,27 cases with extremely severe COPD) admitted to Hebei Chest Hospital from October 2011 to October 2012 who had FEV6 data.FEV6,FEV5,FEV4 and FEV3 were measured on volume-time curves and the diagnostic value was analyzed.Results FEV6,FEV5,FEV4 and FEV3 were highly correlated to FVC (r =0.994,0.939,0.935 and 0.923 respectively,P ＜0.001).Assuming =70％ as the diagnostic standard for obstruction,FEV1/FEV6 had a diagnostic rate of 92.96％ with a false negative rate of 7.04％.FEV1/FEV5,FEV1/FEV4 and FEV1/FEV3 had higher false negative rates (9.86％,13.38％ and 27.46％ respectively) than FEV6.The value of FEV1/FEV6-FEV1/FVC had no statistical significance between the mild-moderate and the severe-extremely severe COPD groups(t =1.376,P =0.171).Conclusion There is a strong correlation between FEV6 and FVC.FEV6 may be the best surrogate for FVC in the diagnosis of chronic obstructive pulmonary disease.Elevating diagnostic critical value can reduce the false negative rate.

Effects of ipratropium bromide oxygen nebulization on pulmonary function of young children with asthma / 重庆医科大学学报

Objective:To investigate the effects of ipratropium bromide(Atrovent)on pulmonary function of young children with asthma.Methods:Type2600 Pediatric Pulmonary Function machine(Sensor Medics,USA)was used to determine the pulmonary function of 30 asthmatic children before and after Atrovent nebulization.Results:After nebulizing with Atrovent,of all the seven indexes there were obvious increase in ?V50,?V25,%T-PF,%V-PF,ME/MI as compared with those before( P

FEV_6 as a surrogate for FVC in the diagnostic screening for chronic obstructive pulmonary disease / 中国实用内科杂志

Objective The purpose of this study was to determine the efficacy of forced expiratory volume in six seconds(FEV6) as an alternative for forced vital capacity(FVC)and the fixed eat-off points for FEV1/FEV6 in the diagnostic screening for chronic obstructive pulmonary disease (COPD).Methods From August 2007 to December 2008,a total of 1210 spirometric examinations in were analyzed,FEV6 was measured on volume-time curves.The correlation between FEV1/FVC and FEV1/FEV6 was evaluated by the Kendall correlation test.Considering FEV1/FVC